For national or local advertisers who are looking to reach consumers at the DMA/Spot Cable level; interconnects enable them to reach the right subscribers. Interconnects, which combine two or more local cable systems and distribute a program or commercial signal simultaneously, allow the advertiser to reach their target with only one buy, one commercial tap and one invoice. This section lists the main interconnects in the Top 50 DMAs.
| Rank | DMA | Interconnect Name | MSO |
| 1 | New York | New York Interconnect | CABLEVISION |
| 1 | New York | Time Warner/Full Zone, NY | TIME WARNER CABLE |
| 2 | Los Angeles | Adlink Interconnect, CA | ADLINK |
| 3 | Chicago | Comcast/Chicago Interconnect, IL | COMCAST |
| 4 | Philadelphia | Comcast/Philadelphia Interconnect, PA | COMCAST |
| 5 | Dallas/Ft. Worth | Time Warner/Dallas-Ft Worth Int., TX | TIME WARNER CABLE |
| 6 | San Fran/Oakland | Comcast/San Francisco Interconnect, CA | COMCAST |
| 7 | Boston | Comcast/Boston Interconnect, MA | COMCAST |
| 8 | Atlanta | Comcast/Atlanta Interconnect, GA | COMCAST |
| 9 | Washington, DC | Comcast/Washington Interconnect, DC | COMCAST |
| 10 | Houston | Comcast/Houston Interconnect, TX | COMCAST |
| 11 | Detroit | Comcast/Detroit Interconnect, MI | COMCAST |
| 12 | Phoenix | Cox Media/Phoenix Interconnect, AZ | COX MEDIA |
| 13 | Seattle/Tacoma | Comcast/Seattle Full Interconnect, WA | COMCAST |
| 14 | Tampa/St. Pete | Tampa Bay Interconnect, FL | BRIGHT HOUSE NETWORKS |
| 14 | Tampa/St. Pete | Comcast/Sarasota Interconnect, FL | COMCAST |
| 15 | Minn/St. Paul | Comcast/Twin Cities Interconnect, MN | COMCAST |
| 16 | Miami/Ft. Lauder | Comcast/Miami-Ft. Lauderdale Int, FL | COMCAST |
| 17 | Denver | Comcast/Denver DMA Interconnect, CO | COMCAST |
| 18 | Cleveland | Cleveland Media Connect, OH | TIME WARNER CABLE |
| 19 | Orlando/Dayt Bch | Central Fla Int/Orlando-Daytona Bch Int | BRIGHT HOUSE NETWORKS |
| 20 | Sacramento/Stktn | Comcast/Sacramento Interconnect, CA | COMCAST |
| 21 | St. Louis | Charter/St. Louis DMA Interconnect, MO | CHARTER |
| 22 | Portland, OR | Comcast/Portland Interconnect, OR | COMCAST |
| 23 | Charlotte | Time Warner/Charlotte (ICLT) Int., NC | TIME WARNER CABLE |
| 24 | Pittsburgh | Comcast/Pittsburgh Interconnect, PA | COMCAST |
| 25 | Raleigh/Durham | Time Warner/Raleigh (IRAL) Int, NC | TIME WARNER CABLE |
| 26 | Baltimore | Comcast/Baltimore Interconnect, MD | COMCAST |
| 27 | Indianapolis | Comcast/Indianapolis Interconnect, IN | COMCAST |
| 28 | San Diego | Cox Media/San Diego Interconnect, CA | COX MEDIA |
| 29 | Nashville | Comcast/Nashville Interconnect, TN | COMCAST |
| 30 | Hartford/New Hvn | Comcast/Hartford-Nw Hvn Interconnect, CT | COMCAST |
| 31 | Kansas City | Time Warner/Kansas City Interconnect, MO | TIME WARNER CABLE |
| 32 | Salt Lake City | Comcast/Salt Lake City Interconnect, UT | COMCAST |
| 34 | Columbus, OH | Time Warner/Columbus Interconnect, OH | TIME WARNER CABLE |
| 35 | Milwaukee | Time Warner/Milwaukee Interconnect, WI | TIME WARNER CABLE |
| 37 | San Antonio | Time Warner/San Antonio Interconnect, TX | TIME WARNER CABLE |
| 38 | West Palm Beach | Comcast/West Palm Beach Int., FL | COMCAST |
| 39 | HLLY | Comcast/HLLY Interconnect, PA | COMCAST |
| 40 | Birmingham | Greater Birmingham Interconnect, AL | CHARTER |
| 41 | Grand Rapids | Comcast/Grand Rapids Interconnect, MI | COMCAST |
| 42 | Las Vegas | Cox Media/Las Vegas-Valley Wide Int., NV | COX MEDIA |
| 43 | Norfolk | Cox Media/Norfolk Interconnect, VA | COX MEDIA |
| 44 | Austin | Time Warner/Austin Interconnect, TX | TIME WARNER CABLE |
| 46 | Albuquerque | Comcast/Albuquerque Interconnect, NM | COMCAST |
| 47 | Grsbro/WnSal/Hpt | Time Warner/Greensboro (IGBO) Int, NC | TIME WARNER CABLE |
| 48 | Memphis | Comcast/Memphis Interconnect, TN | COMCAST |
| 49 | Jacksonville | Comcast/Jacksonville Interconnect, FL | COMCAST |
| 50 | Louisville | Insight Media/Louisville Inter, KY | INSIGHT COMMUN. |